產(chǎn)品名稱：anti-human/mouse PUMA Purified Polyclonal 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-6041-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse PUMA Purified Also known as: bbc3, p53 upregulated modulator of apoptosis Clone: Polyclonal RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6041 Cat. No. Size 14-6041-82 100 ug Description: The polyclonal antibody reacts with human and mouse PUMA. The antibody was raised against a synthetic peptide (plprghrapemepn) corresponding to amino acids 180 to 193 of human PUMA-α. This sequence is identical in α and β forms of the PUMA proteins. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
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