產品名稱：anti-human NKG2D / CD314 (activating) Purified 5C6 100 ug 產品貨號：eBioscience 14-5879-82 產品規(guī)格：100 ug Anti-Human CD314 (NKG2D) Purified Also known as: KLRK1 Clone: 5C6 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5879 Cat. No. Size 14-5879-80 25 ug 14-5879-82 100 ug Description: The 5C6 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, γδ T cells, some CD4+ and CD8+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to γδ TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.
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