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產(chǎn)品名稱：anti-mouse TIM-1 Purified RMT1-10 500 ug 產(chǎn)品貨號(hào)：eBioscience 14-5862-85 產(chǎn)品規(guī)格：500 ug Anti-Mouse TIM1 Purified (To be Discontinued; refer 0to 14-5861) Also known as: TIM-1, HAVCR1, T cell immunoglobulin domain, mucin-like domain Clone: RMT1-10 RUO: For Research Use Only. Not for use in diagnostic procedures. Attention: To be disocntinued. Alternative clone is available as 14-5861. SKU# 14-5862 Cat. No. Size 14-5862-82 100 ug 14-5862-85 500 ug Description: The RMT1-10 monoclonal antibody reacts with mouse TIM-1, a member of newly identified T cell immunoglobulin domain, mucin-like domain (TIM) gene family. RMT1-10 reacts with TIM-1 from C57Bl/6 mouse. RMT1-4, another antibody specific for TIM-1, reacts with the TIM-1 protein from both BALB/c and C57Bl/6 strains. TIM family of proteins are transmembrane proteins expressed by CD4 T cells. Recent studies demonstrate that the TIM family, particularly TIM-1, plays a critical role in immune responses that regulate the development of atopic diseases. Human TIM-1 is a functional receptor for hepatitis A virus (HAV). In humans, certain polymorphic variants of TIM-1 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus (HAV). Activation of T cells through TIM-1 by HAV or by its natural ligand may affect T cell differentiation and the development of Th2-driven allergic inflammatory responses.
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