產(chǎn)品名稱：anti-Notch-1 Purified mN1A 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-5785-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse Notch1 Purified Also known as: Notch-1, TAN1, Motch, Neurogenic locus notch homolog protein 1 Clone: mN1A RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-5785 Cat. No. Size 14-5785-81 50 ug 14-5785-82 100 ug Description: The Notch family of transmembrane receptors controls cell-fate decisions during the development of many organs in a wide variety of species. After binding its ligand, the Notch receptor is cleaved in its transmembrane domain, and the resulting intracellular domain dissociates from the membrane and translocates to the nucleus, where it is able to suppress the expression of lineage-specific genes by interacting with transcriptional repressors. The mN1A antibody reacts with the intracellular domain of mouse and human Notch1, but not with Notch2, 3, or 4. The mN1A antibody has a low affinity for the full-length (unprocessed or heterodimeric cell surface) forms of Notch1. In the mouse, Notch mRNA is expressed in mouse hematopoietic cells of the fetal liver and ***** thymus and bone marrow. In the thymus, Notch1 protein is detected in CD4-CD8- (double-negative) and CD4-CD8+ (single-positive) thymocytes. Studies of Notch1-transgenic cells and Notch1-null mice indicate that the receptor is involved in the regulation of lymphopoiesis and myelopoiesis.
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