產(chǎn)品名稱：Affinity Purified anti-mouse GILZ 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-4033-82 產(chǎn)品規(guī)格：100 ug Anti-Human/Mouse GILZ Purified Also known as: Glucocorticoid-Induced Leucine Zipper, TSC22D3 Clone: CFMKG15 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-4033 Cat. No. Size 14-4033-80 25 ug 14-4033-82 100 ug Description: GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-κB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-κB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining.
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