產品名稱：Affinity purified human POKEMON/LRF (clone 13E9), 100 ug 產品貨號：eBioscience 14-3309-82 產品規(guī)格：100 ug Anti-Human Pokemon (LRF) Purified Also known as: Zinc finger and BTB domain-containing protein 7A , Leukemia/lymphoma-related factor, Zbtb7a Clone: 13E9 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-3309 Cat. No. Size 14-3309-80 25 ug 14-3309-82 100 ug Description: This monoclonal antibody reacts with human Leukemia/lymphoma-related factor (LRF). This 65-kDa protein is also known as POKEMON, FBI-1, and Zbtb7a. LRF is a member of the POK family of transcriptional repressors, and is expressed in hematopoietic stem cells, T and B lymphocytes, macrophages, and erythroid cells. This protein is also highly expressed in human non-Hodgkin’s lymphoma tissues and diffuse large B-cell lymphomas, demonstrating its prominent role in oncogenic transformation. Studies have demonstrated that LRF is also involved in B cell lineage commitment and development by opposing Notch signaling. Moreover, LRF is critical for erythroid terminal differentiation in the bone marrow by inhibiting Bim-mediated apoptosis. Finally, LRF interacts with Bcl-6 in germinal center B cells.
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