產(chǎn)品名稱：anti-human CD101 Purified BB27 100 ug 產(chǎn)品貨號：eBioscience 14-1019-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD101 Purified Also known as: V7 antigen, IGSF 2, IGSF-2, IGSF2 Clone: BB27 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-1019 Cat. No. Size 14-1019-80 25 ug 14-1019-82 100 ug Description: The monoclonal antibody BB27 reacts to human CD101 also known as V7 antigen, a member of the Ig superfamily. CD101 is a disulfide linked homodimer of unknown function. Expression of CD101 is found on monocytes, granulocytes and dendritic cells (Langerhan-like cells HLA-DR, CD1a, CD1c). In addition expression on T lymphocytes is important for cell activation. CD101+ CD28+ cells are very responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can increase proliferation thereby suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit the T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. Recently it has been demonstrated that mouse CD101 is found on a subpopulation of regulatory T cells (CD4, CD25, Foxp3 positive) that have high suppressor activity. Expression of CD101 on human PBMCs shows staining of about 30% of the Foxp3 positive cells. Studies have not confirmed higher suppressor activity in the human CD101 population.
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