產(chǎn)品名稱(chēng)：anti-human CD61 (integrin beta 3) Purified VI-PL2 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-0619-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD61 (Integrin beta 3) Purified Also known as: ITGB3 Clone: VI-PL2 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-0619 Cat. No. Size 14-0619-80 25 ug 14-0619-82 100 ug Description: The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells. This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.
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