產(chǎn)品名稱：anti-human CD47 Purified 2D3 100 ug 產(chǎn)品貨號(hào)：eBioscience 14-0478-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD47 Purified Also known as: Integrin associated protein, IAP, neurophilin Clone: 2D3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-0478 Cat. No. Size 14-0478-80 25 ug 14-0478-82 100 ug Description: The monoclonal antibody 2D3 reacts to CD47 also known as integrin-associated protein (IAP), and neurophilin. CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with SIRP (signal regulator protein) and is non-covalently associated with β3 integrins CD51/CD61 and CD41/CD61. Furthermore this interaction can mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Expression is found in the majority of hematopoietic cells including T and B cells, monocytes, platelets and erythrocytes (as part of the Rh complex). Expression is also found in non-hematopoietic cells.
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