Pepstatin,Pepstatin A,抑肽素,胃蛋白酶抑制劑,
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產(chǎn)品名稱: Pepstatin,Pepstatin A,抑肽素,胃蛋白酶抑制劑,
產(chǎn)品型號(hào): Sigma P4265 5mg
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡(jiǎn)單介紹
Pepstatin,Pepstatin A,抑肽素,胃蛋白酶抑制劑,
Pepstatin,Pepstatin A,抑肽素,胃蛋白酶抑制劑,
的詳細(xì)介紹
Pepstatin,Pepstatin A,抑肽素,胃蛋白酶抑制劑,
胃蛋白酶抑制劑
中文名：抑肽素，胃蛋白酶抑制劑
英文名：Pepstatin，Pepstatin A
PN-Isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-gamma-aminoheptanoyl-L-alanyl-3-hydroxy-
6-methyl-gamma-aminoheptanoic acid，
(3S,4S)-3-Hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-methyl-2-[[(2S)-3-methy
l-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amin
o]-6-methylheptanoic acid; Pepstatin A
分子式:C34H63N5O9
分子量:685.89
Sigma相關(guān)資料如下：
P4265 Sigma Pepstatin A
microbial, ≥75% (HPLC)
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CAS Number:
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26305-03-3
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Linear Formula:
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C34H63N5O9
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Molecular Weight:
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685.89
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Beilstein Registry Number:
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2201362
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EC Number:
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247-600-0
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MDL number:
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MFCD00060740
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PubChem Substance ID:
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24898519
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Description
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Preparation Note
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Pepstatin can be dissolved at 1 mg/ml in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid). The inclusion of acetic acid may be necessary to dissolve this peptide in methanol or DMSO. It has been dissolved at 1 to 2 mg/ml in ethanol, but heat may be required for complete dissolution. Solutions of Pepstatin A can be heated as high as 60 °C without any decomposition of the peptide.
Stock solutions at 1 mg/ml are stable at least a week at 4 °C. A 1 mM solution in methanol or DMSO is stable for months at -20 °C. If solutions become darker yellow, the reagent is hydrolyzing.
A working concentration of 1 μM is stable for at least one day at room temperature.
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Biochem/physiol Actions
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Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.
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性質(zhì)
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biological source
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microbial
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assay
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≥75% (HPLC)
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mp
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233 °C (dec.)(lit.)
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storage temp.
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2-8°C
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**性
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Personal Protective Equipment
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Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
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Safety Statements
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22-24/25
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WGK Germany
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2
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RTECS
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SC6155000
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品名
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產(chǎn)地
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貨號(hào)
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規(guī)格
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單價(jià)
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備注
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Pepstatin胃蛋白酶抑制劑
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Sigma
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P4265
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5mg
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詢價(jià)
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現(xiàn)貨
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