亮抑酶肽, Leupeptin hemisulfate salt,亮肽素,Acetyl-Leu-Leu-Arg-al,Acetyl-Leu-Leu-Arg-a
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產(chǎn)品名稱: 亮抑酶肽, Leupeptin hemisulfate salt,亮肽素,Acetyl-Leu-Leu-Arg-al,Acetyl-Leu-Leu-Arg-a
產(chǎn)品型號(hào): SIGMA L2884 5MG
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
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亮抑酶肽, Leupeptin hemisulfate salt,亮肽素,Acetyl-Leu-Leu-Arg-al,Acetyl-Leu-Leu-Arg-al
亮抑酶肽, Leupeptin hemisulfate salt,亮肽素,Acetyl-Leu-Leu-Arg-al,Acetyl-Leu-Leu-Arg-a
的詳細(xì)介紹
亮抑酶肽, Leupeptin hemisulfate salt,亮肽素,Acetyl-Leu-Leu-Arg-al,Acetyl-Leu-Leu-Arg-al
亮抑酶肽
由玫瑰鏈霉菌Streptomyces roseus MB-26-AI產(chǎn)生的胰蛋白酶抑劑，它是許多蛋白酶抑制劑中的一種。純亮肽素熔點(diǎn)110～140℃，旋光度-56°(c=1.0，甲醇)。溶于水、甲醇、乙醇、丁醇、二甲亞砜，不溶于乙酸乙酯、丙酮、氯仿、己烷等，對Rydon-Smith、坂口呈附哇反應(yīng)，對茚三酮、三氯化鐵、蒽酮、莫利氏呈陽性反應(yīng)。亮肽素可抑制胰蛋白酶、木瓜蛋白酶、組織蛋酶B、血纖維蛋白溶酶、激肽釋放酶等，它的抑制作用與底物呈競爭抑制。亮肽素（Leupeptin）能抑制多種絲氨酸和半胱氨酸蛋白酶；抑肽素（pepstatin）抑制天冬氨酸蛋白酶；抑肽酶（aprotinin）能抑制許多絲氨酸蛋白酶；苯丁抑制劑（bestatin）能抑制氨基酸多肽酶 .
別名：亮肽素
分子式：C20H38N6O4 1/2(H2SO4) H20 分子量： 493.62
CAS＃：103476-89-7
外觀：白色粉末
特性：比旋度(2%, 水)：-84.2--82.2
溶解性：溶于水，參考濃度為10mg/ml，工作濃度為 0.5mg/ml。
儲(chǔ)存液4℃保存一周，-20℃保存6個(gè)月。
Sigma相關(guān)產(chǎn)品信息
Sigma L2884 Leupeptin hemisulfate salt
microbial, ≥90% (HPLC)
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Synonym:
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Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
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CAS Number:
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103476-89-7
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Linear Formula:
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C20H38N6O4 · 1/2H2SO4
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Molecular Weight:
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475.59
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MDL number:
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MFCD00037012
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PubChem Substance ID:
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24896328
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Description
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Analysis Note
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Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.
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Biochem/physiol Actions
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Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain and cathepsin B. No inhibition found with pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
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性質(zhì)
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biological source
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microbial
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assay
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≥90% (HPLC)
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EQP level
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Premium
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solubility
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H2O: 10 mM (Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20 °C.)
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storage temp.
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−20°C
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**性
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Personal Protective Equipment
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Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
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Safety Statements
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22-24/25
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WGK Germany
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3
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參考文獻(xiàn)
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reference
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Aoyagi, T., Inhibitor of trypsin, plasmin, papain and cathepsin B. J. Antibiot. 22, 283, (1969)
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Saino, T., et al. Chem. Pharm. Bull. 30, 2319, (1982)
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Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182, 83-89, (1990)
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Jazwinski, S.M., Preparation of extracts from yeast. Meth. Enzymol. 182, 154-174, (1990)
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, Beynon, R.J. and Bond, ed. Proteolytic Enzymes: A Practical Approach, (1989), 244-245
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品名
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產(chǎn)地
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貨號(hào)
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規(guī)格
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單價(jià)
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備注
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亮抑酶肽Leupeptin
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SIGMA
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L2884
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5MG
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詢價(jià)
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現(xiàn)貨
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