Amethopterin,4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid,氨基碟
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產(chǎn)品名稱: Amethopterin,4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid,氨基碟
產(chǎn)品型號: Sigma A1784 5mg
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Amethopterin,4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid,氨基碟呤,氨碟呤,現(xiàn)貨
Amethopterin,4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid,氨基碟
的詳細介紹
Amethopterin,4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid,氨基碟呤,氨碟呤,現(xiàn)貨
氨基碟呤
中文名:氨基蝶翅素,4-氨基葉酸
英文名: Aminopterin,4-Aminofolic acid,4-Aminopteroyl-L-glutamic acid,
N-{4-[(2,4-Diamino-6-pteridylmethyl)amino]-benzoyl}-L-glutamic acid,4-Amino-PGA
性狀: 黃色針狀結(jié)晶。對光和空氣敏感。溶于氫氧化鈉溶液。熔點230～235℃(分解)。比旋光度[α]20D+18±2°(c=1,0.1mol/L氫氧化鈉溶液中)。有毒。有致畸可能性。
用途: 生化研究,抗葉酸藥.
Sigma相關(guān)資料如下:
Sigma A1784 Aminopterin
~98% (TLC), powder
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Synonym:
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4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid
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CAS Number:
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54-62-6
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Linear Formula:
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C19H20N8O5
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Molecular Weight:
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440.41
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Beilstein Registry Number:
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69045
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EC Number:
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200-209-9
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MDL number:
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MFCD00036692
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PubChem Substance ID:
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24278186
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Description
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Linkage
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More potent, but more toxic, than methotrexate.
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Biochem/physiol Actions
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Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.
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Properties
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assay
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~98% (TLC)
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form
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powder
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color
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yellow
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solubility
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2 M NaOH: 50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)
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DMSO: soluble (Solutions may be stored for 1-2 days at 4°C.)
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abs.
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ε1M/261 nm, 0.1 M NaOH 25,700
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ε1M/282 nm, 0.1 M NaOH 24,500
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ε1M/373 nm, 0.1 M NaOH 8,100
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Gene Information
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human ... FPGS(2356)
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mouse ... Fpgs(14287)
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storage temp.
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−20°C
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Safety
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Personal Protective Equipment
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Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
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Hazard Codes
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T+
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Risk Statements
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61-28
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Safety Statements
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53-28-36/37-45
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RIDADR
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UN2811 6.1/PG 1
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WGK Germany
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3
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RTECS
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MA1050000
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品名
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產(chǎn)地
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貨號
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規(guī)格
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單價
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備注
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Amethopterin/氨基碟呤/氨碟呤
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Sigma
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A1784
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5mg
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詢價
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現(xiàn)貨
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Amethopterin/氨基碟呤/氨碟呤
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Sigma
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A1784
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25mg
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詢價
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現(xiàn)貨
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