Y-27632
MERCK相關(guān)產(chǎn)品資料：
688000 Y-27632 ( Y-27632 ) ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O is also available.
Product number
型號
價格
688000-10MG
10 mg
詢價
688000-1MG
1 mg
688000-5MG
5 mg
產(chǎn)品信息
Form
White solid
Primary Target
p160ROCK
Primary Target Ki
140 nM
Molar mass
338.3
Protect from Light
Yes
Hygrocopic
Packaged under inert gas
Cell permeable
ATP Competitive
Purity
≥95% by HPLC
Solubility
H2O
Chemical formula
C14H21N3O · 2HCl · H2O
CAS number
146986-50-7
Declaration
Sold under license of U.S. Patent 4,997,834 and PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
Store and ship information
Storage
-20°C
Ship
Ambient Temperature Only Harmful
**標(biāo)示
S Phrase
S: 36 Wear suitable protective clothing.
R Phrase
R: 20/21/22
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